If you’re looking for a quick, creamy comfort dinner that never fails to impress, Chicken and Spinach Casserole with Cream Cheese will instantly earn a permanent spot in your weeknight rotation. Every bite is packed with juicy chicken, ribbons of wilted spinach, and the decadence of cream cheese tied together under a golden layer of cheesy mozzarella. This is more than just a casserole — it’s a one-pan hug at the end of a busy day, perfect for meal prepping, family dinners, or anyone who dreams of a little extra indulgence baked right in.

Chicken and Spinach Casserole with Cream Cheese Recipe - Recipe Image

Ingredients You’ll Need

Let’s talk about the building blocks of flavor that make this dish irresistible. You only need a handful of approachable ingredients to yield a meal that tastes like you spent all day in the kitchen. Each one plays its own part, adding creaminess, depth, or a fresh pop of color and nutrition.

Chicken Breasts: The star of the show, and using thin-sliced cutlets ensures every forkful cooks up tender and juicy.
Olive Oil: Adds flavor and helps create that golden sear on the spinach and the chicken.
Garlic: Infuses the entire casserole with rich, aromatic warmth.
Italian Seasoning: Brings classic, herby notes that make every bite taste like home.
Salt: Elevates all the other flavors without overpowering.
Black Pepper: Adds just the right amount of gentle heat and depth.
Fresh Spinach: Provides vibrant color and a mild, earthy base that complements the creaminess so well.
Cream Cheese: The hero ingredient that melts into silky perfection for that luscious texture.
Shredded Mozzarella Cheese: Melts to form a bubbly blanket of gooey goodness on top.
Parmesan Cheese (optional): Offers a sharp, nutty boost if you’d like an extra layer of flavor.

How to Make Chicken and Spinach Casserole with Cream Cheese

Step 1: Prep Your Chicken

Start by preheating your oven to 400°F (200°C) and greasing a 9×13-inch baking dish. Slice your chicken breasts in half horizontally so you get four evenly-sized cutlets. Use a meat mallet or rolling pin to gently pound any thicker parts, making sure each piece will cook at the same speed — no dry edges or underdone centers here!

Step 2: Marinate for Big Flavor

In a bowl, whisk together one tablespoon of olive oil, all the minced garlic, Italian seasoning, salt, and black pepper. This quick marinade will infuse the chicken with herby, garlicky flavor even before it hits the oven. Toss your chicken in the mixture, cover it, and pop it in the fridge for 15 to 30 minutes.

Step 3: Wilt the Spinach

Heat your remaining tablespoon of olive oil in a skillet over medium heat. Add the fresh spinach and cook for just 2 to 3 minutes until it’s gloriously wilted and deep green. Remove the pan from the heat and let the spinach cool — it’s about to get cozy with the cream cheese.

Step 4: Mix the Creamy Layer

Beat the softened cream cheese in a bowl until it’s smooth, then stir in your spinach and half of the mozzarella cheese. If you opted for Parmesan (highly recommended), fold that in for nutty depth. This mixture will melt into a velvety, savory topping with every bite.

Step 5: Sear the Chicken (Optional but Flavorful!)

If you want to intensify the flavor even further, sear each marinated chicken cutlet in a hot skillet for just a minute or two on each side. This step isn’t required, but it adds a lovely golden crust and extra dimension.

Step 6: Assemble and Bake

Arrange your chicken in the prepared baking dish. Spread the spinach and cream cheese mixture over the top, smoothing it to cover each piece thoroughly. Sprinkle the rest of the mozzarella over everything. Bake for 20 to 30 minutes, until the cheese is bubbly and lightly golden, and the chicken hits an internal temp of 165°F (75°C). Let the Chicken and Spinach Casserole with Cream Cheese rest five minutes before diving in to help all those luscious juices settle.

How to Serve Chicken and Spinach Casserole with Cream Cheese

Garnishes

This casserole already has a stunning, cheese-pull-worthy finish, but a sprinkle of fresh herbs like basil or parsley right before serving really makes the green pop. For a little extra flair, add a dusting of grated Parmesan or a crack of black pepper just before hitting the table.

Side Dishes

The rich flavors of Chicken and Spinach Casserole with Cream Cheese love to be paired with something that balances out the creaminess. Fluffy rice, mashed potatoes, or roasted vegetables are all wonderful choices. Even a crisp garden salad with a sharp vinaigrette makes a perfect partner for this indulgent bake.

Creative Ways to Present

Get playful with presentation by serving the casserole in individual ramekins for a dinner party feel, or make it the star of a brunch spread with some toasted sourdough on the side. For a twist, stuff the creamy spinach mixture into hollowed-out roasted bell peppers and place a piece of chicken inside before baking — it’s a showstopper for any gathering!

Make Ahead and Storage

Storing Leftovers

Leftover Chicken and Spinach Casserole with Cream Cheese keeps beautifully in an airtight container in the fridge for up to three days. The flavors actually get even better as they mingle, making lunch or dinner the next day a total treat.

Freezing

If you want to prep ahead or have extra portions, freeze the cooled casserole (cut into single servings if you like) in well-sealed containers for up to two months. Just be sure to let it thaw in the fridge overnight before reheating to help maintain that creamy, smooth texture.

Reheating

Warm individual portions in the microwave for a minute or two, or reheat the whole casserole in a 350°F (175°C) oven until bubbly and heated through. If needed, add a splash of milk or a sprinkle of cheese on top to freshen things up.

FAQs

Can I use frozen spinach instead of fresh?

Absolutely! Just make sure to thoroughly thaw and squeeze out all the moisture from the frozen spinach before mixing it with the cream cheese, so your Chicken and Spinach Casserole with Cream Cheese stays nice and creamy, not watery.

Can I substitute chicken thighs for breasts?

Yes, chicken thighs are a great choice for this casserole if you prefer darker, juicier meat. Trim off any excess fat and proceed with the recipe exactly the same way for delicious results.

Is this casserole gluten free?

Yes, as written, Chicken and Spinach Casserole with Cream Cheese is naturally gluten free, so it’s a crowd-pleaser even for those avoiding wheat.

What other cheeses work well here?

If you want to change up the flavors, try adding smoked gouda, a sprinkle of feta, or even sharp cheddar to the mix for extra punch and personality. This dish is delightfully flexible!

Can I prep this ahead of time?

You sure can. Assemble everything (up to the baking step), cover, and refrigerate for up to 24 hours. When ready to serve, just pop the Chicken and Spinach Casserole with Cream Cheese right into the oven and bake as directed.

Final Thoughts

I truly hope you give Chicken and Spinach Casserole with Cream Cheese a try. It’s creamy, comforting, and loaded with those little details that make a meal memorable. Whether you’re feeding your family, meal prepping for the week, or just craving a bit of warmth on a busy night, this casserole is here for you — ready to be enjoyed, shared, and loved!

Chicken and Spinach Casserole with Cream Cheese Recipe